Androgens and estrogens are known to be critical regulators of mammalian physiology and
development. While these two classes of steroids share similar structures (in general …

Background The androgen receptor (AR) is expressed frequently in breast cancer, but its
prognostic significance is unclear. Preclinical data suggest that expression of AR may …

Despite significant progress in breast cancer (BC) therapy, it is globally the most commonly
diagnosed cancer and leads to the death of over 650,000 women annually. Androgen …

Purpose: Androgen receptor (AR) is commonly expressed in breast cancers. However, the
association between tumor AR status and breast cancer survival is uncertain. Hence, we …

Previous studies have demonstrated that androgen receptor is expressed in many breast
cancers, but its expression in relation to the various breast cancer subtypes as defined by …

Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in
normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive …

Background The objective of the study was to evaluate the implications of androgen receptor
(AR) in breast cancers. Patients and methods We investigated immunohistochemical AR …

Abstract Lessons Learned The combination of enobosarm and pembrolizumab was well
tolerated and showed a modest clinical benefit rate of 25% at 16 weeks. Future trials …

The androgen receptor (AR) has been shown to be of potential prognostic importance in
retrospective cohorts. We evaluated immunohistochemical AR expression on a tissue …

Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that is involved in epigenetic
regulation of gene expression through methylating histone or non-histone proteins, and …