The cross-talk between receptors represents an important mechanism of neurotransmission
modulation and plasticity. It can occur by direct physical interactions as in the case of G …

Rationale The prefrontal cortex (PFC) mediates executive functions, a set of control
processes that optimize performance on cognitive tasks. It enables appropriate decision …

Nicotinic acetylcholine receptors (nAChRs) are expressed widely in the CNS, and mediate
both synaptic and perisynaptic activities of endogenous cholinergic inputs and …

Refractoriness to existing medications of up to 80% of the patients with mesial temporal lobe
epilepsy (MTLE) prompts for finding new antiepileptic drug targets. The adenosine A 2A …

Objective Thirty percent of patients with epilepsy are refractory to medication. The majority of
these patients have mesial temporal lobe epilepsy (MTLE). This prompts for new …

Objective: ATP-gated ionotropic P2X7 receptors (P2X7R) actively participate in epilepsy and
other neurological disorders. Neocortical nerve terminals of patients with Mesial Temporal …

Synaptic vesicles segregate into functionally diverse subpopulations within presynaptic
terminals, yet there is no information about how this may occur. Here we demonstrate that a …

Acetylcholine (ACh), an ubiquitous mediator substance broadly expressed in nature, acts as
neurotransmitter in cholinergic synapses, generating specific communications with different …

BACKGROUND AND PURPOSE The present work aimed to investigate whether and
through which mechanisms selective α7 and α4β2 nicotinic receptor (nAChR) agonists …

Sodium-dependent high-affinity amino-acid transporters play crucial roles in terminating
synaptic transmission in the central nervous system (CNS). However, there is lack of …