As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

Dental primary afferent (DPA) neurons and proprioceptive mesencephalic trigeminal
nucleus (MTN) neurons, located in the trigeminal ganglion and the brainstem, respectively …

Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike
most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms …

Pain in trigeminal areas is driven by nociceptive trigeminal afferents. Transduction
molecules, among them the nonspecific cation channels transient receptor potential …

Mechanical forces play important roles in many biological processes and there is increasing
interest and understanding of these roles. Mechanotransduction is the process by which …

The role of the hypothalamic cold-sensitive ion channels-transient receptor potential
melastatin 8 (TRPM8) and transient receptor potential ankyrin 1 (TRPA1) in homeostatic …

Since its first identification in prostate cancers and prostate tissues, transient receptor
potential melastatin-subfamily member 8 (TRPM8) is subsequently found to be …

Cold sensation is initiated in the periphery by a specialized population of cold-sensitive
neurons, referred to as cold receptors, who transmit decreases in temperature with sub …

TRPM8 is a non-selective cation channel expressed in primary sensory neurons and other
tissues, including the prostate and urothelium. Its participation in different physiological and …