Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Insulin resistance (IR) is a condition which refers to individuals whose cells and tissues
become insensitive to the peptide hormone, insulin. Over the recent years, a wealth of data …

Targeting metabolic vulnerability of tumor cells is a promising anticancer strategy. However,
the therapeutic efficacy of existing metabolism‐regulating agents is often compromised due …

Background RNA-binding proteins (RBPs) and circular RNAs (circRNAs) play important
roles in glioblastoma multiforme (GBM). Aerobic glycolysis is a metabolic characteristic of …

Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a
barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms …

The diagnosis and treatment of triple‐negative breast cancer (TNBC) is still a grand
challenge, because there is rare target to be manipulated. Here, an integrated functional …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor
prognosis and limited therapeutic options. Research on the tumor microenvironment (TME) …

Patients with cholangiocarcinoma (CCA) often have an unfavorable prognosis because of its
insidious nature, low resectability rate, and poor response to anticancer drugs and …

Ionizing radiation (IR) is a form of high energy. It poses a serious threat to organisms, but
radiotherapy is a key therapeutic strategy for various cancers. It is significant to reduce …

The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …