The 600% increase in medical radiation exposure to the US population since 1980 has
provided immense benefit, but increased potential future cancer risks to patients. Most of the …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

O 6-Alkylguanine-DNA alkyltransferase (AGT) is a widely distributed, unique DNA repair
protein that acts as a single agent to directly remove alkyl groups located on the O 6-position …

Purpose Glioblastoma (GBM) is the most common and aggressive type of glioma and has
the poorest survival. However, a small percentage of patients with GBM survive well beyond …

In gliomas, germline gene alterations play a significant role during malignant transformation
of progenitor glial cells, at least for families with occurrence of multiple cancers or with …

Although primary brain tumors (PBTs) are generally considered to be a multifactorial
disorder, understanding the genetic basis and etiology of the disease is essential for PBT …

Two genome-wide association studies of glioma in European populations identified 14
genetic variants strongly associated with risk of glioma, but it is unknown whether these …

Background Association studies of germline DNA repair single nucleotide polymorphisms
(SNPs) and glioma risk have yielded inconclusive results. We therefore performed a …

DNA damage response (DDR) comprising DNA repair and cell-cycle checkpoint pathways,
is considered as a protective process that maintains the integrity of the genome. However …

Recent advances in human genome studies have opened new avenues for the identification
of susceptibility genes for many complex genetic disorders, especially in the field of rare …