Mannich bases in medicinal chemistry and drug design
G Roman - European journal of medicinal chemistry, 2015 - Elsevier
The biological activity of Mannich bases, a structurally heterogeneous class of chemical
compounds that are generated from various substrates through the introduction of an …
compounds that are generated from various substrates through the introduction of an …
Acetate as a potential feedstock for the production of value-added chemicals: metabolism and applications
Acetate is regarded as a promising carbon feedstock in biological production owing to its
possible derivation from C 1 gases such as CO, CO 2 and methane. To best use of acetate …
possible derivation from C 1 gases such as CO, CO 2 and methane. To best use of acetate …
Catalytic active centers beyond transition metals: Atomically dispersed alkaline-earth metals for the electroreduction of nitrate to ammonia
Alkaline-earth (AE) metals have rarely been reported to be the active centers in
heterogeneous catalysis. However, in nature, Mg cofactors in enzymes exhibit super activity …
heterogeneous catalysis. However, in nature, Mg cofactors in enzymes exhibit super activity …
[HTML][HTML] Turning main-group element magnesium into a highly active electrocatalyst for oxygen reduction reaction
It is known that the main-group metals and their related materials show poor catalytic activity
due to a broadened single resonance derived from the interaction of valence orbitals of …
due to a broadened single resonance derived from the interaction of valence orbitals of …
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection
S Nair, JP Huynh, V Lampropoulou… - Journal of Experimental …, 2018 - rupress.org
Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under
inflammatory conditions, principally in cells of myeloid lineage. Cell culture studies suggest …
inflammatory conditions, principally in cells of myeloid lineage. Cell culture studies suggest …
[HTML][HTML] Role of glyoxylate shunt in oxidative stress response
The glyoxylate shunt (GS) is a two-step metabolic pathway (isocitrate lyase, aceA; and
malate synthase, glcB) that serves as an alternative to the tricarboxylic acid cycle. The GS …
malate synthase, glcB) that serves as an alternative to the tricarboxylic acid cycle. The GS …
Mechanism of Candida pathogenesis: revisiting the vital drivers
Candida is the most implicated fungal pathogen in the clinical setting. Several factors play
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …
Integrated analysis of the effects of cold and dehydration on rice metabolites, phytohormones, and gene transcripts
K Maruyama, K Urano, K Yoshiwara… - Plant …, 2014 - academic.oup.com
Correlations between gene expression and metabolite/phytohormone levels under abiotic
stress conditions have been reported for Arabidopsis (Arabidopsis thaliana). However, little …
stress conditions have been reported for Arabidopsis (Arabidopsis thaliana). However, little …
Antifungal drugs: New insights in research & development
The need for better antifungal therapy is commonly accepted in view of the high mortality
rates associated with systemic infections, the low number of available antifungal classes …
rates associated with systemic infections, the low number of available antifungal classes …
Novel agents and drug targets to meet the challenges of resistant fungi
MW McCarthy, DP Kontoyiannis… - The Journal of …, 2017 - academic.oup.com
The emergence of drug-resistant fungi poses a major threat to human health. Despite
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …