[HTML][HTML] Rationale for the use of N‐acetylcysteine in both prevention and adjuvant therapy of COVID‐19

S De Flora, R Balansky, S La Maestra - The FASEB journal, 2020 - ncbi.nlm.nih.gov
COVID‐19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular
alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a …

[HTML][HTML] Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

RM Liu, LP Desai - Redox biology, 2015 - Elsevier
Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …

[HTML][HTML] Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

RI Horowitz, PR Freeman, J Bruzzese - Respiratory medicine case reports, 2020 - Elsevier
Purpose Infection with COVID-19 potentially can result in severe outcomes and death from
“cytokine storm syndrome”, resulting in novel coronavirus pneumonia (NCP) with severe …

ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

M Kellner, S Noonepalle, Q Lu, A Srivastava… - … redox signaling in …, 2017 - Springer
The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential

PMD Potey, AG Rossi, CD Lucas… - The Journal of …, 2019 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is the often fatal sequelae of a broad range of
precipitating conditions. Despite decades of intensive research and clinical trials there …

Pharmacological agents for adults with acute respiratory distress syndrome

SR Lewis, MW Pritchard, CM Thomas… - Cochrane Database of …, 2019 - cochranelibrary.com
Background Acute respiratory distress syndrome (ARDS) is a life‐threatening condition
caused by direct or indirect injury to the lungs. Despite improvements in clinical …

[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation

CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

RM Liu, KAG Pravia - Free Radical Biology and Medicine, 2010 - Elsevier
Transforming growth factor β (TGF-β) is the most potent and ubiquitous profibrogenic
cytokine, and its expression is increased in almost all the fibrotic diseases and in …

Inflammatory response leads to neuronal death in human post-mortem cerebral cortex in patients with COVID-19

ME Boroujeni, L Simani, HAR Bluyssen… - ACS chemical …, 2021 - ACS Publications
The recent coronavirus disease of 2019 (COVID-19) pandemic has adversely affected
people worldwide. A growing body of literature suggests the neurological complications and …

[HTML][HTML] Paracetamol-induced glutathione consumption: is there a link with severe COVID-19 illness?

P Sestili, C Fimognari - Frontiers in Pharmacology, 2020 - frontiersin.org
COVID-19 pandemic is posing an unprecedented sanitary threat: antiviral and host-directed
medications to treat the disease are urgently needed. A great effort has been paid to find …