The human fungal pathogen Cryptococcus neoformans is characterized by its ability to
induce a distinct polysaccharide capsule in response to a number of host-specific …

Folding and processing of proteins in the endoplasmic reticulum (ER) are major
impediments in the production and secretion of proteins from Pichia pastoris (Komagataella …

Cryptococcus neoformans causes life-threatening meningoencephalitis in humans, but its
overall biological and pathogenic regulatory circuits remain elusive, particularly due to the …

Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or
activity can significantly alter the infection process, and enzyme expression profiles can be a …

Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis;
however, treatment options remain limited. Here we report the construction of 264 signature …

The endoplasmic reticulum (ER) controls many important aspects of cellular function,
including processing of secreted and membrane proteins, synthesis of membranes, and …

The unfolded protein response (UPR) is a network of signaling pathways that responds to
stress in the endoplasmic reticulum (ER). The general output of the UPR is to upregulate …

During plant‐pathogenic fungi and host plants interactions, numerous pathogen‐derived
proteins are secreted resulting in the activation of the unfolded protein response (UPR) …

Background Alternative splicing (AS) regulation is extensive and shapes the functional
complexity of higher organisms. However, the contribution of alternative splicing to fungal …

Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …