[HTML][HTML] Mitochondrial form and function in hair cells

JDB O'Sullivan, A Bullen, ZF Mann - Hearing Research, 2023 - Elsevier
Hair cells (HCs) are specialised sensory receptors residing in the neurosensory epithelia of
inner ear sense organs. The precise morphological and physiological properties of HCs …

[HTML][HTML] Nanodelivery of antioxidant Agents: A promising strategy for preventing sensorineural hearing loss

Z Hajmohammadi, Z Bagher… - European Journal of …, 2024 - Elsevier
Sensorineural hearing loss (SNHL), often stemming from reactive oxygen species (ROS)
generation due to various factors such as ototoxic drugs, acoustic trauma, and aging …

[HTML][HTML] Ethylbenzene induces hearing loss by triggering mitochondrial impairments and excess apoptosis in cochlear progenitor cells via suppressing the Wnt/β …

M Zhang, T Qu, S Liu, F Yu, L Fan, D Lin… - Ecotoxicology and …, 2023 - Elsevier
Ethylbenzene (EB) is widely distributed at low levels in the environment from vehicle
emissions, industrial discharge, cigarette smoke, and in some food and consumer products …

Calcium signaling and genetic rare diseases: An auditory perspective

EM Richard, T Maurice, B Delprat - Cell Calcium, 2023 - Elsevier
Deafness is a highly heterogeneous disorder which stems, for 50%, from genetic origins.
Sensory transduction relies mainly on sensory hair cells of the cochlea, in the inner ear …

Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels

X Fu, P Wan, L Lu, Y Wan, Z Liu, G Hong… - Advanced …, 2023 - Wiley Online Library
The peroxisome is a ubiquitous organelle in rodent cells and plays important roles in a
variety of cell types and tissues. It is previously indicated that peroxisomes are associated …

Direct targeting of mitochondria by cisplatin leads to cytotoxicity in zebrafish lateral-line hair cells

DS Lee, A Schrader, J Zou, WH Ang, ME Warchol… - Iscience, 2024 - cell.com
Cisplatin is a chemotherapy drug that causes permanent hearing loss by injuring cochlear
hair cells. Hair cell mitochondria have emerged as potential mediators of hair cell …

Hair cell toxicology: with the help of a little fish

A Barrallo-Gimeno, J Llorens - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Hearing or balance loss are disabling conditions that have a serious impact in those
suffering them, especially when they appear in children. Their ultimate cause is frequently …

[HTML][HTML] Development of the inner ear and regeneration of hair cells after hearing impairment

X Bing, C Liu, X Cao, C Li, X Gao, F Zhu, X Wu… - Fundamental …, 2023 - Elsevier
Hearing loss, as a sensory disorder, is the most common occurrence among humans, which
has received increasing attention from society. It is mainly caused by the damage of inner …

Sublethal effects of methylmercury on lateral line sensory and ion-regulatory functions in zebrafish embryos

GY Hung, YC Pan, JL Horng, LY Lin - … and Physiology Part C: Toxicology & …, 2023 - Elsevier
Methylmercury can interfere with the normal functioning of the nervous system, causing a
variety of behavioral and physiological changes in fish. However, the influence of MeHg on …

cdh23 affects congenital hearing loss through regulating purine metabolism

S Yang, BL Xie, X Dong, L Wang, G Zhu… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction The pathogenic gene CDH23 plays a pivotal role in tip links, which is
indispensable for mechanoelectrical transduction in the hair cells. However, the underlying …