The increase of many deadly diseases like infections by multidrug-resistant bacteria implies
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …

It has been estimated that over a billion dollars in resources can be consumed to obtain
clinical approval, and only a few new chemical entities are approved by the US Food and …

Cytotoxicity is one of the most important indicators for biological evaluation in vitro studies. In
vitro, chemicals such as drugs and pesticides have different cytotoxicity mechanisms such …

Mesenchymal stem cells (MSCs) have opposite effects on tumor growth, being able either to
favor angiogenesis and tumor initiation or to inhibit progression of established tumors …

Major histocompatibility complex (MHC) class I molecules present peptides on the cell
surface to CD8+ T cells, which is critical for the killing of virus-infected or transformed cells …

The use of nanotechnology in medical products has been demonstrated at laboratory scale,
and many resulting nanomedicines are in the translational phase toward clinical …

Background Nanomedicine is a very promising field and nanomedical drugs have recently
been used as therapeutic agents against cancer. In a previous study, we showed that …

Apoptosis is an important and necessary cell death program which promotes homeostasis
and organismal survival. When dysregulated, however, it can lead to a myriad of pathologies …

Large-scale pharmacogenomic high-throughput screening (HTS) studies hold great
potential for generating robust genomic predictors of drug response. Two recent large-scale …

Progresses made in previous researches on syntheses of dithiocarbamates led to increase
in further researches. This paper reviews concisely the challenges experienced during the …