DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …

Background Whole-genome bisulfite sequencing (WGBS) is becoming an increasingly
accessible technique, used widely for both fundamental and disease-oriented research …

Here we present APOBEC-coupled epigenetic sequencing (ACE-seq), a bisulfite-free
method for localizing 5-hydroxymethylcytosine (5hmC) at single-base resolution with low …

The presence of 5-methylcytidine (m5C) in tRNA and rRNA molecules of a wide variety of
organisms was first observed more than 40 years ago. However, detection of this …

DNA methylation, which most commonly occurs at the C5 position of cytosines within CpG
dinucleotides, plays a pivotal role in many biological procedures such as gene expression …

DNA methylation, ie, addition of methyl group to 5′-carbon of cytosine residues in CpG
dinucleotides, is an important epigenetic modification regulating gene expression, and thus …

PerlPrimer is a cross-platform graphical user interface application for the design of primers
for standard, bisulphite and real-time PCR, and sequencing. The program incorporates …

The methylation of cytosine to 5-methylcytosine (5-meC) is an important epigenetic DNA
modification in many bacteria, plants, and mammals, but its relevance for important model …

DNA methylation is a critical regulatory mechanism implicated in development, learning,
memory, and disease in the human brain. Here we have elucidated DNA methylation …