Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Genetic association studies have identified 215 risk loci for inflammatory bowel disease,,,,,,,,
thereby uncovering fundamental aspects of its molecular biology. We performed a genome …
thereby uncovering fundamental aspects of its molecular biology. We performed a genome …
The effect of host genetics on the gut microbiome
The gut microbiome is affected by multiple factors, including genetics. In this study, we
assessed the influence of host genetics on microbial species, pathways and gene ontology …
assessed the influence of host genetics on microbial species, pathways and gene ontology …
Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution
M van Iterson, EW van Zwet, Bios Consortium… - Genome biology, 2017 - Springer
We show that epigenome-and transcriptome-wide association studies (EWAS and TWAS)
are prone to significant inflation and bias of test statistics, an unrecognized phenomenon …
are prone to significant inflation and bias of test statistics, an unrecognized phenomenon …
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney
Elevated blood pressure is a major risk factor for cardiovascular disease and has a
substantial genetic contribution. Genetic variation influencing blood pressure has the …
substantial genetic contribution. Genetic variation influencing blood pressure has the …
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
The genetic architecture of human reproductive behavior—age at first birth (AFB) and
number of children ever born (NEB)—has a strong relationship with fitness, human …
number of children ever born (NEB)—has a strong relationship with fitness, human …
Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in
humans remains poorly understood. While DNA methylation at many CpG sites closely …
humans remains poorly understood. While DNA methylation at many CpG sites closely …
Identification of 15 novel risk loci for coronary artery disease and genetic risk of recurrent events, atrial fibrillation and heart failure
N Verweij, RN Eppinga, Y Hagemeijer… - Scientific reports, 2017 - nature.com
Coronary artery disease (CAD) is the major cause of morbidity and mortality in the world.
Identification of novel genetic determinants may provide new opportunities for developing …
Identification of novel genetic determinants may provide new opportunities for developing …
Local genetic effects on gene expression across 44 human tissues
Expression quantitative trait locus (eQTL) mapping provides a powerful means to identify
functional variants influencing gene expression and disease pathogenesis. We report the …
functional variants influencing gene expression and disease pathogenesis. We report the …
Validity of LIDAS (LIfetime Depression Assessment Self-report): a self-report online assessment of lifetime major depressive disorder
M Bot, CM Middeldorp, EJC De Geus, HM Lau… - Psychological …, 2017 - cambridge.org
BackgroundThere is a paucity of valid, brief instruments for the assessment of lifetime major
depressive disorder (MDD) that can be used in, for example, large-scale genomics, imaging …
depressive disorder (MDD) that can be used in, for example, large-scale genomics, imaging …
К вопросу об иммунологических маркерах сыворотки крови в диагностике воспалительных заболеваний кишечника
ИГ Бакулин, ЕБ Авалуева, ИА Оганезова - Opinion Leader, 2020 - elibrary.ru
Иммунологические маркеры сыворотки крови—кандидаты на роль биомаркеров при
воспалительных заболеваниях кишечника. В обзоре представлены современные …
воспалительных заболеваниях кишечника. В обзоре представлены современные …