Melatonin and health: insights of melatonin action, biological functions, and associated disorders

SB Ahmad, A Ali, M Bilal, SM Rashid, AB Wani… - Cellular and Molecular …, 2023 - Springer
Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many
living organisms. In human beings, pineal gland is the major site for melatonin production …

[HTML][HTML] Melatonin synthesis and function: evolutionary history in animals and plants

D Zhao, Y Yu, Z Zhao, R Sharma… - Frontiers in …, 2019 - frontiersin.org
Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's
initial function was likely that as a free radical scavenger. Melatonin presumably evolved in …

Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease

DM Chitimus, MR Popescu, SE Voiculescu… - Biomolecules, 2020 - mdpi.com
There is a growing consensus that the antioxidant and anti-inflammatory properties of
melatonin are of great importance in preserving the body functions and homeostasis, with …

Light pollution is a driver of insect declines

ACS Owens, P Cochard, J Durrant, B Farnworth… - Biological …, 2020 - Elsevier
Insects around the world are rapidly declining. Concerns over what this loss means for food
security and ecological communities have compelled a growing number of researchers to …

Melatonin as an antioxidant: under promises but over delivers

RJ Reiter, JC Mayo, DX Tan, RM Sainz… - Journal of pineal …, 2016 - Wiley Online Library
Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Melatonin as a hormone: new physiological and clinical insights

J Cipolla-Neto, FG Amaral - Endocrine reviews, 2018 - academic.oup.com
Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Environmental risks from artificial nighttime lighting widespread and increasing across Europe

A Sánchez de Miguel, J Bennie, E Rosenfeld… - Science …, 2022 - science.org
The nighttime environment of much of Earth is being changed rapidly by the introduction of
artificial lighting. While data on spatial and temporal variation in the intensity of artificial …

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

LC Manchester, A Coto‐Montes, JA Boga… - Journal of pineal …, 2015 - Wiley Online Library
Melatonin is remarkably functionally diverse with actions as a free radical scavenger and
antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule …

Mitochondria: central organelles for melatonin′ s antioxidant and anti-aging actions

RJ Reiter, DX Tan, S Rosales-Corral, A Galano… - Molecules, 2018 - mdpi.com
Melatonin, along with its metabolites, have long been known to significantly reduce the
oxidative stress burden of aging cells or cells exposed to toxins. Oxidative damage is a …

Melatonin as a potent and inducible endogenous antioxidant: synthesis and metabolism

DX Tan, LC Manchester, E Esteban-Zubero, Z Zhou… - Molecules, 2015 - mdpi.com
Melatonin is a tryptophan-derived molecule with pleiotropic activities. It is present in almost
all or all organisms. Its synthetic pathway depends on the species in which it is measured …