Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

abstract Atopic dermatitis (AD) is characterized by chronic, eczematous, severe pruritic skin
lesions. The knowledge on the pathogenesis of AD is driving the development of new drugs …

Background Dupilumab is an IL-4 receptor α mAb inhibiting signaling of IL-4 and IL-13, key
drivers of type 2–driven inflammation, as demonstrated by its efficacy in patients with …

Background Moderate-to-severe asthma remains poorly treated. We evaluated the efficacy
and safety of dupilumab (SAR231893/REGN668), a fully human monoclonal antibody to the …

Background Severe atopic dermatitis (AD) has a high unmet need for effective and safe
therapeutics. In early-phase trials, dupilumab, a fully human mAb targeting IL-4 receptor α …

Janus kinase (JAK) enzymes are involved in cell signaling pathways activated by various
cytokines dysregulated in allergy. The objective of this study was to determine whether the …

We found for the first time that IL-4 and IL-13, signature type 2 cytokines, are able to induce
periostin expression. We and others have subsequently shown that periostin is highly …

abstract Interleukin (IL)-4 and IL-13, signature type 2 cytokines, exert their actions by binding
to two types of receptors sharing the IL-4R a chain (IL-4Ra). Since IL-4 and IL-13 play …

Rationale: IL-4 and IL-13 share many biological functions important in the development of
allergic airway inflammation and are implicated in the pathogenesis of asthma. AMG 317 is …

Periostin is a matricellular protein as well as an extracellular matrix (ECM) protein belonging
to the fasciclin family. Periostin plays important roles as a matricellular protein in the setting …