[HTML][HTML] iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders
H Okano, S Morimoto - Cell Stem Cell, 2022 - cell.com
It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …
technology in 2007, and the scope of its application has been expanding. In addition to the …
[HTML][HTML] Astrocytes: a double-edged sword in neurodegenerative diseases
ZB Ding, LJ Song, Q Wang, G Kumar… - Neural regeneration …, 2021 - journals.lww.com
Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the
central nervous system by regulating homeostasis, increasing synaptic plasticity, and …
central nervous system by regulating homeostasis, increasing synaptic plasticity, and …
ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response
ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …
Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis
Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular
functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is …
functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is …
Modeling sporadic Alzheimer's disease in human brain organoids under serum exposure
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no cure. Huge
efforts have been made to develop anti‐AD drugs in the past decades. However, all drug …
efforts have been made to develop anti‐AD drugs in the past decades. However, all drug …
Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma
D Wang, R Starr, WC Chang, B Aguilar… - Science translational …, 2020 - science.org
Although chimeric antigen receptor (CAR) T cells have demonstrated signs of antitumor
activity against glioblastoma (GBM), tumor heterogeneity remains a critical challenge. To …
activity against glioblastoma (GBM), tumor heterogeneity remains a critical challenge. To …
CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation
W Jiang, F Zhu, H Xu, L Xu, H Li, X Yang… - Science …, 2023 - science.org
Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain
and is known as a reliable biomarker for inflammatory central nervous system (CNS) …
and is known as a reliable biomarker for inflammatory central nervous system (CNS) …
Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest
known genetic risk factor for late-onset Alzheimer's disease. However, whether this single …
known genetic risk factor for late-onset Alzheimer's disease. However, whether this single …
Potential role of chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) in neurodegeneration and Alzheimer's disease
K Connolly, M Lehoux, R O'Rourke… - Alzheimer's & …, 2023 - Wiley Online Library
Abstract Chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) has long been known as a biomarker
for early detection of neuroinflammation and disease diagnosis of Alzheimer's disease (AD) …
for early detection of neuroinflammation and disease diagnosis of Alzheimer's disease (AD) …
Induced pluripotent stem cell (iPSC)-based neurodegenerative disease models for phenotype recapitulation and drug screening
Neurodegenerative diseases represent a significant unmet medical need in our aging
society. There are no effective treatments for most of these diseases, and we know …
society. There are no effective treatments for most of these diseases, and we know …