Laminin 332 is crucial in the biology of epithelia. This large extracellular matrix protein
consists of the heterotrimeric assembly of three subunits–α3, β3, and γ2–and its …

The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …

VLGR1 (very large G protein-coupled receptor-1) is by far the largest adhesion G protein-
coupled receptor in humans. Homozygous pathologic variants of VLGR1 cause hereditary …

In mammals, integrins are heterodimeric transmembrane glycoproteins that represent a
large group of cell adhesion receptors involved in cell–cell, cell–extracellular matrix, and cell …

Intestinal epithelia are critical for maintaining gastrointestinal homeostasis. Epithelial barrier
injury, causing inflammation and vascular damage, results in inflammatory hypoxia, and …

The epidermis is a specialized epithelium that constitutes the outermost layer of the skin,
and it provides a protective barrier against environmental assaults. Primarily consisting of …

Recent studies have revealed that aberrant expression of tight junction (TJ) proteins is a
hallmark of various solid tumors and it is recognized as a useful therapeutic target. Claudin …

We find that clusters of β4 integrin, organized into distinct puncta, localize along vimentin
filaments within lamellipodia at the cell edge of A549 cells, as assessed by interferometric …

The epithelial cytoskeleton encompasses actin filaments, microtubules, and keratin
intermediate filaments. They are interconnected and attached to the extracellular matrix via …

Down syndrome is a neurodevelopmental disorder frequently characterized by other
developmental defects, such as congenital heart disease. Analysis of gene expression …