Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

J Zhao, J Yang, Y Xie - International journal of pharmaceutics, 2019 - Elsevier
Although flavonoid compounds have various pharmacological applications, they generally
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …

A review of microencapsulation methods for food antioxidants: Principles, advantages, drawbacks and applications

G Ozkan, P Franco, I De Marco, J Xiao, E Capanoglu - Food chemistry, 2019 - Elsevier
Bioactivities and numerous health benefits against a number of oxidative stress related
diseases have been attributed to the role of dietary antioxidants. The development of …

Introducing nano/microencapsulated bioactive ingredients for extending the shelf-life of food products

H Hosseini, SM Jafari - Advances in Colloid and Interface Science, 2020 - Elsevier
The shelf-life of foods is affected by several aspects, mainly chemical and microbial events,
resulting in a considerable decline in consumer's acceptance. There is an increasing …

[HTML][HTML] Quercetin: a potential polydynamic drug

N Georgiou, MG Kakava, EA Routsi, E Petsas… - Molecules, 2023 - mdpi.com
The study of natural products as potential drug leads has gained tremendous research
interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and …

Novel findings for quercetin encapsulation and preservation with cyclodextrins, liposomes, and drug-in-cyclodextrin-in-liposomes

J Azzi, A Jraij, L Auezova, S Fourmentin… - Food …, 2018 - Elsevier
The low solubility, poor bioavailability, and low chemical stability of quercetin (Quer) are the
main drawbacks that limit its use as a food nutraceutical. In this study, the encapsulation in …

Tuning the pharmacokinetic performance of quercetin by cocrystallization

MM Haskins, ON Kavanagh, R Sanii… - Crystal Growth & …, 2023 - ACS Publications
Quercetin (QUE) is a widely studied nutraceutical with a number of potential therapeutic
properties. Although QUE is abundant in the plant kingdom, its poor solubility (≤ 20 μg/mL) …

[HTML][HTML] The mechanism of bensulfuron-methyl complexation with β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin and effect on soil adsorption and bio-activity

Q Geng, T Li, X Wang, W Chu, M Cai, J Xie, H Ni - Scientific Reports, 2019 - nature.com
In this work, the inclusion complexes of hydrophobic herbicide bensulfuron-methyl (BSM)
with β-cyclodextrin (β-CD) and (2-hydroxypropyl)-β-CD (2-HP-β-CD) were prepared and …

[HTML][HTML] Quercetin loaded monolaurate sugar esters-based niosomes: Sustained release and mutual antioxidant—hepatoprotective interplay

E Elmowafy, MO El-Derany, F Biondo, M Tiboni… - Pharmaceutics, 2020 - mdpi.com
Flavonoids possess different interesting biological properties, including antibacterial,
antiviral, anti-inflammatory and antioxidant activities. However, unfortunately, these …

Mapping the interactions and bioactivity of quercetin⿿(2-hydroxypropyl)-β-cyclodextrin complex

TF Kellici, MV Chatziathanasiadou, D Diamantis… - International Journal of …, 2016 - Elsevier
Natural products have served as a rich source for drug discovery and development. In the
last decade their fruitful integration in the drug discovery pipeline declined due to their …

Administration routes for nano drugs and characterization of nano drug loading

V Nikolić, S Ilić-Stojanović, S Petrović, A Tačić… - … and biology of …, 2019 - Elsevier
This chapter summarizes the types of nano drugs, their synthesis, formulation,
characterization, and applications, with the most important administration routes. To achieve …