Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues,
or whole organisms, has undergone a rapid technological evolution in the past two decades …

Breakthrough technologies to measure cellular oxygen consumption and proton efflux are
reigniting the study of cellular energetics by increasing the scope and pace with which …

G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …

Pancreatic islet β cells secrete insulin in response to nutrient secretagogues, like glucose,
dependent on calcium influx and nutrient metabolism. One of the most intriguing qualities of …

Brown adipose tissue (BAT) activation stimulates energy expenditure in human adults,
which makes it an attractive target to combat obesity and related disorders. Recent studies …

The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review
applies an external bioenergetic critique to the central processes of glucose-stimulated …

Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2
diabetes etiology, resulting from FA overload, oxidative stress, intermediate …

Itaconic acid is an important metabolite produced by macrophages after stimulation with
LPS. The role of itaconate in the inflammatory cascade is unclear. Here we used [13 C] …

Obesity is the major contributing factor for the increased prevalence of type 2 diabetes (T2D)
in recent years. Sustained positive influx of lipids is considered to be a precipitating factor for …