Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems
G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …
synthesis of new anticancer metallodrugs, which have received special attention due to their …
NAMI-A and KP1019/1339, two iconic ruthenium anticancer drug candidates face-to-face: A case story in medicinal inorganic chemistry
NAMI-A ((ImH)[trans-RuCl4 (dmso-S)(Im)], Im= imidazole) and KP1019/1339
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …
Thirty years of the drug candidate NAMI‐A and the myths in the field of ruthenium anticancer compounds: a personal perspective
E Alessio - European Journal of Inorganic Chemistry, 2017 - Wiley Online Library
As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
Interactive association of drugs binding to human serum albumin
Human serum albumin (HSA) is an abundant plasma protein, which attracts great interest in
the pharmaceutical industry since it can bind a remarkable variety of drugs impacting their …
the pharmaceutical industry since it can bind a remarkable variety of drugs impacting their …
Developing drug molecules for therapy with carbon monoxide
The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …
Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities
Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …
animal cells is a widespread area of research, yet little is known about the reactivity and …
Vanadium (IV) complexes of salicylaldehyde-based furoic acid hydrazones: Synthesis, BSA binding and in vivo antidiabetic potential
Solution synthesis afforded five novel neutral heteroleptic octahedral paramagnetic
mononuclear oxidovanadium (IV) complexes of general composition [VO (bpy) L], where L is …
mononuclear oxidovanadium (IV) complexes of general composition [VO (bpy) L], where L is …
Ruthenium complexes as promising candidates against lung cancer
Q Sun, Y Li, H Shi, Y Wang, J Zhang, Q Zhang - Molecules, 2021 - mdpi.com
Lung cancer is one of the most common malignancies with the highest mortality rate and the
second-highest incidence rate after breast cancer, posing a serious threat to human health …
second-highest incidence rate after breast cancer, posing a serious threat to human health …
Metal-based antitumor compounds: Beyond cisplatin
PV Simpson, NM Desai, I Casari, M Massi… - Future Medicinal …, 2019 - Taylor & Francis
Despite improvements in the 5-year survival rate to over 80% in cancers, such as Hodgkin
lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain …
lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain …
CORM-3 reactivity toward proteins: the crystal structure of a Ru (II) dicarbonyl− lysozyme complex
T Santos-Silva, A Mukhopadhyay… - Journal of the …, 2011 - ACS Publications
CORM-3,[fac-Ru (CO) 3Cl (κ2-H2NCH2CO2)], is a well-known carbon monoxide releasing
molecule (CORM) capable of delivering CO in vivo. Herein we show for the first time that the …
molecule (CORM) capable of delivering CO in vivo. Herein we show for the first time that the …