Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Roles of oxytocin in stress responses, allostasis and resilience

Y Takayanagi, T Onaka - International journal of molecular sciences, 2021 - mdpi.com
Oxytocin has been revealed to work for anxiety suppression and anti-stress as well as for
psychosocial behavior and reproductive functions. Oxytocin neurons are activated by …

Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment

E McMoneagle, J Zhou, S Zhang, W Huang… - Acta Pharmacologica …, 2024 - nature.com
Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …

Neural functions of hypothalamic oxytocin and its regulation

P Wang, SC Wang, X Liu, S Jia, X Wang, T Li… - ASN …, 2022 - journals.sagepub.com
Oxytocin (OT), a nonapeptide, has a variety of functions. Despite extensive studies on OT
over past decades, our understanding of its neural functions and their regulation remains …

Oxytocin-based therapies for treatment of Prader-Willi and Schaaf-Yang syndromes: evidence, disappointments, and future research strategies

F Althammer, F Muscatelli, V Grinevich… - Translational …, 2022 - nature.com
The prosocial neuropeptide oxytocin is being developed as a potential treatment for various
neuropsychiatric disorders including autism spectrum disorder (ASD). Early studies using …

A short period of early life oxytocin treatment rescues social behavior dysfunction via suppression of hippocampal hyperactivity in male mice

L Pan, L Zheng, X Wu, Z Zhu, S Wang, Y Lu, Y He… - Molecular …, 2022 - nature.com
Early sensory experiences interact with genes to shape precise neural circuits during
development. This process is vital for proper brain function in adulthood. Neurological …

Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring

T Wang, B Chen, M Luo, L Xie, M Lu, X Lu, S Zhang… - Microbiome, 2023 - Springer
Background Autism spectrum disorder (ASD) has been associated with intrauterine growth
restriction (IUGR), but the underlying mechanisms are unclear. Results We found that the …

Oxytocin alleviates cognitive and memory impairments by decreasing hippocampal microglial activation and synaptic defects via OXTR/ERK/STAT3 pathway in a …

J Jiang, Y Zou, C Xie, M Yang, Q Tong, M Yuan… - Brain, Behavior, and …, 2023 - Elsevier
Background Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction,
characterized by cognitive and memory impairments closely linked to hippocampal …

The role of oxytocin in abnormal brain development: effect on glial cells and neuroinflammation

M Knoop, ML Possovre, A Jacquens, A Charlet, O Baud… - Cells, 2022 - mdpi.com
The neonatal period is critical for brain development and determinant for long-term brain
trajectory. Yet, this time concurs with a sensitivity and risk for numerous brain injuries …

Transient demyelination causes long‐term cognitive impairment, myelin alteration and network synchrony defects

O Mercier, PP Quilichini, K Magalon, F Gil, A Ghestem… - Glia, 2024 - Wiley Online Library
In the adult brain, activity‐dependent myelin plasticity is required for proper learning and
memory consolidation. Myelin loss, alteration, or even subtle structural modifications can …