Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
Roles of oxytocin in stress responses, allostasis and resilience
Y Takayanagi, T Onaka - International journal of molecular sciences, 2021 - mdpi.com
Oxytocin has been revealed to work for anxiety suppression and anti-stress as well as for
psychosocial behavior and reproductive functions. Oxytocin neurons are activated by …
psychosocial behavior and reproductive functions. Oxytocin neurons are activated by …
Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment
E McMoneagle, J Zhou, S Zhang, W Huang… - Acta Pharmacologica …, 2024 - nature.com
Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …
Neural functions of hypothalamic oxytocin and its regulation
P Wang, SC Wang, X Liu, S Jia, X Wang, T Li… - ASN …, 2022 - journals.sagepub.com
Oxytocin (OT), a nonapeptide, has a variety of functions. Despite extensive studies on OT
over past decades, our understanding of its neural functions and their regulation remains …
over past decades, our understanding of its neural functions and their regulation remains …
Oxytocin-based therapies for treatment of Prader-Willi and Schaaf-Yang syndromes: evidence, disappointments, and future research strategies
F Althammer, F Muscatelli, V Grinevich… - Translational …, 2022 - nature.com
The prosocial neuropeptide oxytocin is being developed as a potential treatment for various
neuropsychiatric disorders including autism spectrum disorder (ASD). Early studies using …
neuropsychiatric disorders including autism spectrum disorder (ASD). Early studies using …
A short period of early life oxytocin treatment rescues social behavior dysfunction via suppression of hippocampal hyperactivity in male mice
Early sensory experiences interact with genes to shape precise neural circuits during
development. This process is vital for proper brain function in adulthood. Neurological …
development. This process is vital for proper brain function in adulthood. Neurological …
Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring
T Wang, B Chen, M Luo, L Xie, M Lu, X Lu, S Zhang… - Microbiome, 2023 - Springer
Background Autism spectrum disorder (ASD) has been associated with intrauterine growth
restriction (IUGR), but the underlying mechanisms are unclear. Results We found that the …
restriction (IUGR), but the underlying mechanisms are unclear. Results We found that the …
Oxytocin alleviates cognitive and memory impairments by decreasing hippocampal microglial activation and synaptic defects via OXTR/ERK/STAT3 pathway in a …
J Jiang, Y Zou, C Xie, M Yang, Q Tong, M Yuan… - Brain, Behavior, and …, 2023 - Elsevier
Background Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction,
characterized by cognitive and memory impairments closely linked to hippocampal …
characterized by cognitive and memory impairments closely linked to hippocampal …
The role of oxytocin in abnormal brain development: effect on glial cells and neuroinflammation
The neonatal period is critical for brain development and determinant for long-term brain
trajectory. Yet, this time concurs with a sensitivity and risk for numerous brain injuries …
trajectory. Yet, this time concurs with a sensitivity and risk for numerous brain injuries …
Transient demyelination causes long‐term cognitive impairment, myelin alteration and network synchrony defects
O Mercier, PP Quilichini, K Magalon, F Gil, A Ghestem… - Glia, 2024 - Wiley Online Library
In the adult brain, activity‐dependent myelin plasticity is required for proper learning and
memory consolidation. Myelin loss, alteration, or even subtle structural modifications can …
memory consolidation. Myelin loss, alteration, or even subtle structural modifications can …