The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Chronic inflammation is a pathological condition characterized by continued active
inflammation response and tissue destruction. Many of the immune cells including …

Mesoporous silica nanoparticles (MSNs) are emerging as one of the promising
nanomaterials for biomedical applications, but the nanomaterials–body interaction exposed …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Prediction of chemical-induced hepatotoxicity in humans from in vitro data continues to be a
significant challenge for the pharmaceutical and chemical industries. Generally …

Achieving efficient in vivo delivery of siRNA to the appropriate target cell would be a major
advance in the use of RNAi in gene function studies and as a therapeutic modality …

Kupffer cells are resident liver macrophages and play a critical role in maintaining liver
functions. Under physiological conditions, they are the first innate immune cells and protect …

Despite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural
products and their derived biomolecules are potential resources to mine for novel anti …

Drug-induced liver injury (DILI) is the major cause for liver failure and post-marketing drug
withdrawals. Due to species-specific differences in hepatocellular function, animal …