Lipoprotein lipase (LPL) is a rate-limiting enzyme that catalyzes hydrolysis of the triglyceride
(TG) core of circulating TG-rich lipoproteins including chylomicrons (CM), low-density …

Mitochondrial oxidation of fatty acids accounts for the majority of cardiac ATP production in
the heart. Fatty acid utilization by cardiac mitochondria is controlled at the level of fatty acid …

Abstract Objective Angiopoietin-like 4 (ANGPTL4) is a fasting-induced inhibitor of lipoprotein
lipase (LPL) and a regulator of plasma triglyceride metabolism. Here, we examined the …

Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the
underlying molecular mechanisms for diabetic cardiomyopathy/heart failure are poorly …

Numerous preclinical models have been developed to advance biomedical research in type
1 diabetes mellitus (T1DM). They are essential for improving our knowledge of T1DM …

Obese patients have higher levels of free fatty acids (FFAs) in their plasma and a higher risk
of cancer than their non-obese counterparts. However, the mechanisms involved in the …

Background Diabetic cardiomyopathy (DbCM) is characterized by initial impairment of left
ventricular relaxation followed by contractile dysfunction. Despite intensive research, the …

Objective ANGPTL7 is a member of the Angiopoietin-like (ANGPTL) protein family that is
composed of eight proteins (1–8). Increasing evidence is associating ANGPTL proteins to …

Atrial fibrillation (AF) is the more significant portion of arrhythmia in clinical practice, with
inflammation and fibrosis as its central pathological mechanisms. This study aimed to …

Triacylglycerols (TAGs) constitute the main energy storage resource in mammals, by virtue
of their high energy density. This in turn is a function of their highly reduced state and …