The growing applications of SuFEx click chemistry

AS Barrow, CJ Smedley, Q Zheng, S Li… - Chemical Society …, 2019 - pubs.rsc.org
SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions,
geared towards the rapid and reliable assembly of functional molecules. This review …

Sulfonyl fluorides as privileged warheads in chemical biology

A Narayanan, LH Jones - Chemical science, 2015 - pubs.rsc.org
Sulfonyl fluoride electrophiles have found significant utility as reactive probes in chemical
biology and molecular pharmacology. As warheads they possess the right balance of …

EnT-mediated N–S bond homolysis of a bifunctional reagent leading to aliphatic sulfonyl fluorides

JE Erchinger, R Hoogesteger, R Laskar… - Journal of the …, 2023 - ACS Publications
Sulfur (VI) fluoride exchange (SuFEx) gives rise to a plethora of high-valent sulfur linkages;
however, the availability of (aliphatic) sulfonyl fluoride manifolds lag behind, owing to the …

Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF

C Patel, E André-Joyaux, JA Leitch… - Science, 2023 - science.org
All fluorochemicals—including elemental fluorine and nucleophilic, electrophilic, and radical
fluorinating reagents—are prepared from hydrogen fluoride (HF). This highly toxic and …

Radical Hydro‐Fluorosulfonylation of Unactivated Alkenes and Alkynes

P Wang, H Zhang, M Zhao, S Ji, L Lin… - Angewandte Chemie …, 2022 - Wiley Online Library
Recently, radical fluorosulfonylation is emerging as an appealing approach for the synthesis
of sulfonyl fluorides, which are highly in demand in various disciplines, particularly in …

Ethenesulfonyl fluoride (ESF): an on-water procedure for the kilogram-scale preparation

Q Zheng, J Dong, KB Sharpless - The Journal of Organic …, 2016 - ACS Publications
A two-step, on-water procedure for the synthesis of ethenesulfonyl fluoride (ESF) is
described. 2-Chloroethanesulfonyl fluoride is made via a neat reaction with an aqueous …

Ethenesulfonyl fluoride (ESF) and its derivatives in SuFEx click chemistry and more

YP Meng, SM Wang, WY Fang, ZZ Xie, J Leng… - …, 2020 - thieme-connect.com
The sulfur (VI) fluoride exchange reaction (SuFEx), developed by Sharpless and co-workers
in 2014, is a new category of click reaction that creates molecular connections with absolute …

An easy, general and practical method for the construction of alkyl sulfonyl fluorides

X Zhang, WY Fang, R Lekkala… - Advanced Synthesis & …, 2020 - Wiley Online Library
A visible light‐induced reductive addition of 1°, 2° and 3° alkyl iodides to ethenesulfonyl
fluoride, employing Hantzsch ester as a hydrogen source at room temperature was …

Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction

JA Sierra-Fonseca, O Najera, J Martinez-Jurado… - BMC neuroscience, 2014 - Springer
Background Assembly and disassembly of microtubules (MTs) is critical for neurite
outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces …

Hydrophobic Amplification Enabled High‐Turnover Phosphazene Superbase Catalysis

SB Lee, JH Park, HY Bae - ChemSusChem, 2022 - Wiley Online Library
Abstract β‐Sulfido sulfonyl fluoride and its derivatives have been gaining attention recently
in the fields of medicinal chemistry and material science. The conventional method for the …