DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …

At each cell division in humans, 30,000–50,000 DNA replication origins are activated, and it
remains unclear how they are selected and recognized by replication factors. DNA …

We report the genome-wide mapping of ORC1 binding sites in mammals, by chromatin
immunoprecipitation and parallel sequencing (ChIP-seq). ORC1 binding sites in HeLa cells …

The initiation of chromosomal DNA replication involves initiator proteins that recruit and load
hexameric DNA helicases at replication origins. This helicase loading step is tightly …

The ciliate Tetrahymena thermophila has been a powerful model system for molecular and
cellular biology. However, some investigations have been limited due to the incomplete …

In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the
genetic material between generations requires timely and accurate duplication of DNA by …

Protein-RNA interactions play important roles in many biological processes. Given the high
cost and technique difficulties in experimental methods, computationally predicting the …

Origin recognition complex (ORC), consisting of six subunits ORC1–6, is known to bind to
replication origins and function in the initiation of DNA replication in eukaryotic cells. In …

Origin recognition complex (ORC) proteins were first discovered as a six-subunit
assemblage in budding yeast that promotes the initiation of DNA replication. Orc1-5 appear …

Abstract The Protein–RNA Interface Database (PRIDB) is a comprehensive database of
protein–RNA interfaces extracted from complexes in the Protein Data Bank (PDB). It is …