Genome size is a biodiversity trait that shows staggering diversity across eukaryotes, varying
over 64,000-fold. Of all major taxonomic groups, land plants stand out due to their …

Housekeeping genes are involved in basic cell maintenance and, therefore, are expected to
maintain constant expression levels in all cells and conditions. Identification of these genes …

The intron–exon architecture of many eukaryotic genes raises the intriguing question of
whether this unique organization serves any function, or is it simply a result of the spread of …

Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

We show that genes with rapidly changing expression levels in response to stress contain
significantly lower intron densities in yeasts, thale cress and mice. Therefore, we propose …

Using a collection of expressed sequence tag (EST) data, we re-evaluated the correlation of
tissue specificity with genomic structure, phyletic age, evolutionary rate and promoter …

DNA methylation of transcription units (gene bodies) occurs in the genomes of many animal
and plant species. Phylogenetic persistence of gene body methylation implies biological …

Background RNAs transcribed from intronic regions of genes are involved in a number of
processes related to post-transcriptional control of gene expression. However, the …

Introns can be extraordinarily large and they account for the majority of the DNA sequence in
human genes. However, little is known about their population patterns of structural variation …

Background Categorizing protein-encoding transcriptomes of normal tissues into
housekeeping genes and tissue-selective genes is a fundamental step toward studies of …