Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease.
HCM is a highly complex and heterogeneous disease regarding not only the number of …

Over the last 2 decades, the pathogenic basis for the most common heritable cardiovascular
disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting …

Background—Whether morphological abnormalities of the mitral valve represent part of the
hypertrophic cardiomyopathy (HCM) disease process is unresolved. Therefore, we applied …

Genetic studies in the 1980s and 1990s led to landmark discoveries that sarcomere
mutations cause both hypertrophic and dilated cardiomyopathies. Sarcomere mutations also …

During the past two decades, numerous disease-causing genes for different
cardiomyopathies have been identified. These discoveries have led to better understanding …

Hypertrophic cardiomyopathy (HCM), defined clinically by the presence of unexplained left
ventricular hypertrophy, is the most common inherited cardiac disorder. This condition is the …

Hypertrophic cardiomyopathy (HCM) is a common inherited monogenic disease with a
prevalence of 1/500 in the general population, representing an important cause of …

Hypertrophic Cardiomyopathy (HCM), a common and clinically heterogeneous disease
characterized by unexplained ventricular myocardial hypertrophy and a high risk of sudden …

The current repertoire of HCM genes allows effective gene-based diagnosis, information that
enables accurate assessment of disease risk in family members, and provides some insight …

BACKGROUND: TTN-encoded titin, CSRP3-encoded muscle LIM protein, and TCAP-
encoded telethonin are Z-disc proteins essential for the structural organization of the cardiac …