The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here,
we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without …

Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women
to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte …

Objective To investigate the beneficial role of prebiotics on endothelial dysfunction, an early
key marker of cardiovascular diseases, in an original mouse model linking steatosis and …

In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects
including improvements in heart failure (HF), reduced blood pressure, prevention of the …

Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many
cellular processes, including transcytosis of macromolecules, cholesterol transport, and …

Over the last two decades, it has become evident that decreased bioavailability of
endothelial nitric oxide (NO) produced from endothelial NO synthase (eNOS), referred to as …

The mouse is the animal model principally used to study biological processes in mammals.
The mutation, overexpression or knockout of one or several genes can provide insight into …

Statins reduce cholesterol synthesis and are widely used for the treatment of
hyperlipidaemia and ischaemic heart disease. Besides their cholesterol-lowering effects …