Angiogenic factors as potential drug target: efficacy and limitations of anti-angiogenic therapy

RN Gacche, RJ Meshram - Biochimica et Biophysica Acta (BBA)-Reviews …, 2014 - Elsevier
Formation of new blood vessels (angiogenesis) has been demonstrated to be a basic
prerequisite for sustainable growth and proliferation of tumor. Several growth factors …

PlGF: a multitasking cytokine with disease-restricted activity

M Dewerchin, P Carmeliet - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF)
family that also comprises VEGF-A (VEGF), VEGF-B, VEGF-C, and VEGF-D. Unlike VEGF …

Exercise training and peripheral arterial disease

TL Haas, PG Lloyd, HT Yang… - Comprehensive …, 2012 - Wiley Online Library
Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow
capacity to the legs of patients. PAD leads to exercise intolerance that can progress in …

Gene expression responses of HeLa cells to chemical species generated by an atmospheric plasma flow

M Yokoyama, K Johkura, T Sato - Biochemical and biophysical research …, 2014 - Elsevier
Plasma irradiation generates many factors able to affect the cellular condition, and this
feature has been studied for its application in the field of medicine. We previously reported …

Low molecular weight heparin promotes transcription and release of placental growth factor from endothelial cells

K McLaughlin, L Nadeem, J Wat… - American Journal …, 2020 - journals.physiology.org
Circulating levels of placental growth factor (PlGF) are significantly reduced in women who
develop preeclampsia. Low molecular weight heparin (LMWH) has been shown to acutely …

[HTML][HTML] The intricate cellular ecosystem of human peripheral veins as revealed by single-cell transcriptomic analysis

MG Rojas, ZM Zigmond, S Pereira-Simon… - PloS one, 2024 - journals.plos.org
The venous system has been historically understudied despite its critical roles in blood
distribution, heart function, and systemic immunity. This study dissects the microanatomy of …

Fluid shear stress upregulates placental growth factor in the vessel wall via NADPH oxidase 4

NA Rashdan, PG Lloyd - American Journal of Physiology …, 2015 - journals.physiology.org
Placental growth factor (PLGF), a potent stimulator of arteriogenesis, is upregulated during
outward arterial remodeling. Increased fluid shear stress (FSS) is a key physiological …

Influences of placental growth factor on mouse retinal vascular development

VR Kay, C Tayade, P Carmeliet… - Developmental …, 2017 - Wiley Online Library
Background: Placental growth factor (PGF) is important for wound‐healing and vascular
collaterogenesis. PGF deficiency is associated with preeclampsia, a hypertensive disease of …

Placental growth factor triggers epithelial‐to‐mesenchymal transition‐like changes in rat type ii alveolar epithelial cells: activation of nuclear factor κB signalling …

L Zhang, S Zhao, L Yuan, H Wu… - Basic & Clinical …, 2016 - Wiley Online Library
Epithelial‐to‐mesenchymal transition (EMT) occurs frequently in lung epithelium in
response to damage stimuli, such as inflammation and oxidative stress. Our group has …

Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide

JH Shaw, PG Lloyd - Microvascular research, 2012 - Elsevier
In tissues containing pre-existing collateral vessels, occlusion of an upstream supply artery
results in diversion of blood flow through these vessels, protecting the distal tissue from …