[HTML][HTML] Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
TH Baryakova, BH Pogostin, R Langer… - Nature Reviews Drug …, 2023 - nature.com
Poor medication adherence is a pervasive issue with considerable health and
socioeconomic consequences. Although the underlying reasons are generally understood …
socioeconomic consequences. Although the underlying reasons are generally understood …
Discontinuation, suboptimal adherence, and reinitiation of oral HIV pre-exposure prophylaxis: a global systematic review and meta-analysis
Background Poor adherence to oral HIV pre-exposure prophylaxis (PrEP) diminishes its
clinical and public health benefits. This study synthesises evidence regarding …
clinical and public health benefits. This study synthesises evidence regarding …
Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a …
KH Mayer, JM Molina, MA Thompson, PL Anderson… - The Lancet, 2020 - thelancet.com
Background Tenofovir alafenamide shows high antiviral efficacy and improved renal and
bone safety compared with tenofovir disoproxil fumarate when used for HIV treatment. Here …
bone safety compared with tenofovir disoproxil fumarate when used for HIV treatment. Here …
Clinical targeting of HIV capsid protein with a long-acting small molecule
JO Link, MS Rhee, WC Tse, J Zheng, JR Somoza… - Nature, 2020 - nature.com
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV,
and can prevent new infections via pre-exposure prophylaxis,,,–. However, some people …
and can prevent new infections via pre-exposure prophylaxis,,,–. However, some people …
Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2018 recommendations of the International Antiviral Society–USA Panel
MS Saag, CA Benson, RT Gandhi, JF Hoy… - Jama, 2018 - jamanetwork.com
Importance Antiretroviral therapy (ART) is the cornerstone of prevention and management of
HIV infection. Objective To evaluate new data and treatments and incorporate this …
HIV infection. Objective To evaluate new data and treatments and incorporate this …
[HTML][HTML] Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label …
S McCormack, DT Dunn, M Desai, DI Dolling, M Gafos… - The Lancet, 2016 - thelancet.com
Background Randomised placebo-controlled trials have shown that daily oral pre-exposure
prophylaxis (PrEP) with tenofovir–emtricitabine reduces the risk of HIV infection. However …
prophylaxis (PrEP) with tenofovir–emtricitabine reduces the risk of HIV infection. However …
[HTML][HTML] Artificial intelligence and the implementation challenge
Background Applications of artificial intelligence (AI) in health care have garnered much
attention in recent years, but the implementation issues posed by AI have not been …
attention in recent years, but the implementation issues posed by AI have not been …
[HTML][HTML] The prevalence of pre-exposure prophylaxis use and the pre-exposure prophylaxis–to-need ratio in the fourth quarter of 2017, United States
Purpose The number of individuals who have started a regimen for HIV pre-exposure
prophylaxis (PrEP) in the United States is not well characterized but has been on the rise …
prophylaxis (PrEP) in the United States is not well characterized but has been on the rise …
Preexposure prophylaxis for the prevention of HIV infection: evidence report and systematic review for the US Preventive Services Task Force
Importance Effective prevention strategies for HIV infection are an important public health
priority. Preexposure prophylaxis (PrEP) involves use of antiretroviral therapy (ART) daily or …
priority. Preexposure prophylaxis (PrEP) involves use of antiretroviral therapy (ART) daily or …
Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study
RM Grant, PL Anderson, V McMahan, A Liu… - The Lancet infectious …, 2014 - thelancet.com
Background The effect of HIV pre-exposure prophylaxis (PrEP) depends on uptake,
adherence, and sexual practices. We aimed to assess these factors in a cohort of HIV …
adherence, and sexual practices. We aimed to assess these factors in a cohort of HIV …