Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

The human genome contains 19 putatively functional aldehyde dehydrogenase (ALDH)
genes, which encode enzymes critical for detoxification of endogenous and exogenous …

Chemotherapy is one of the standard methods of treatment in many cancers. While
chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk …

Sphere-forming assays have been widely used to retrospectively identify stem cells based
on their reported capacity to evaluate self-renewal and differentiation at the single-cell level …

Increased understanding of the molecular heterogeneity that is intrinsic to the various
subtypes of breast cancer will likely shape the future of breast cancer diagnosis, prognosis …

Tumors may be initiated and maintained by a cellular subcomponent that displays stem cell
properties. We have used the expression of aldehyde dehydrogenase as assessed by the …

Although the concept that cancers originate from stem cells (SC) is becoming scientifically
accepted, mechanisms by which SC contribute to tumor initiation and progression are …

Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have
the capacity to self-renew and differentiate into multiple cell types. In both the normal stem …

Resistance to current chemotherapeutic or radiation-based cancer treatment strategies is a
serious concern. Cancer stem cells (CSCs) are typically able to evade treatment and …

Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer deaths among women in
the United States, but its pathogenesis is poorly understood,,. Some epithelial cancers are …