[HTML][HTML] The road to precision medicine: Eliminating the “One Size Fits All” approach in Alzheimer's disease

T Behl, I Kaur, A Sehgal, S Singh, A Albarrati… - Biomedicine & …, 2022 - Elsevier
The expeditious advancement of Alzheimer's Disease (AD) is a threat to the global
healthcare system, that is further supplemented by therapeutic failure. The prevalence of this …

Exercise training for preventing dementia, mild cognitive impairment, and clinically meaningful cognitive decline: a systematic review and meta-analysis

P de Souto Barreto, L Demougeot… - The Journals of …, 2018 - academic.oup.com
Background To assess the effects of long-term exercise on the onset of dementia, mild
cognitive impairment (MCI), and other clinically meaningful cognitive decline in the elderly …

Methylphenidate for apathy in community-dwelling older veterans with mild Alzheimer's disease: a double-blind, randomized, placebo-controlled trial

PR Padala, KP Padala, SY Lensing… - American Journal of …, 2018 - Am Psychiatric Assoc
Objective: Apathy is a common behavioral problem in Alzheimer's disease. Apathy has
profound consequences, such as functional impairment, higher service utilization, higher …

Leisure-time physical activity and the risk of incident dementia: the mayo clinic study of aging

J Krell-Roesch, NT Feder, RO Roberts… - Journal of …, 2018 - content.iospress.com
We conducted a prospective cohort study derived from the population-based Mayo Clinic
Study of Aging. We investigated if leisure-time physical activity among individuals with mild …

APOEε4 and risk of Alzheimer's disease – time to move forward

I Lefterov, NF Fitz, Y Lu, R Koldamova - Frontiers in Neuroscience, 2023 - frontiersin.org
The inheritance of Apolipoprotein E4 (APOEε4) brings the highest genetic risk of Alzheimer's
disease (AD), arguably the highest genetic risk in human pathology. Since the discovery of …

[HTML][HTML] Lifetime physical activity and late-life mild cognitive impairment in community-dwelling older adults

K Makino, P Raina, LE Griffith, S Lee, K Harada… - Journal of the American …, 2024 - Elsevier
Objectives Regular physical activity throughout life is generally recommended to prevent
dementia; however, there is little evidence regarding the association between lifetime …

Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review

J de Frutos-Lucas, N Frost, KI Erickson… - Ageing Research …, 2020 - Elsevier
Introduction For decades, researchers have tried to understand the moderating effect of
APOE ε4 carriage on the relationship between physical activity (PA), brain health and …

Physical activity and cognitive function: between-person and within-person associations and moderators

A Stenling, DE Sörman, M Lindwall… - Aging …, 2021 - Taylor & Francis
In the present study, we decomposed between-and within-person effects and examined
moderators of the longitudinal physical activity-cognition association. Participants (N= 1722) …

[HTML][HTML] Physical activity and beta-amyloid pathology in Alzheimer's disease: A sound mind in a sound body

K Ebrahimi, A Majdi, B Baghaiee, SH Hosseini… - EXCLI …, 2017 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common type of dementia worldwide. Since curative
treatment has not been established for AD yet and due to heavy financial and psychological …

Precision medicine for Alzheimer's disease prevention

CL Berkowitz, L Mosconi, O Scheyer… - The Road from …, 2020 - taylorfrancis.com
The role that genetics plays in the development of late-onset Alzheimer's disease (AD) has
been widely studied, with one study estimating genetics to account for more than 50% of the …