The role of microbiota in infant health: from early life to adulthood

Y Yao, X Cai, Y Ye, F Wang, F Chen… - Frontiers in …, 2021 - frontiersin.org
From early life to adulthood, the microbiota play a crucial role in the health of the infant. The
microbiota in early life are not only a key regulator of infant health but also associated with …

The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis

N Gomez-Lopez, J Galaz, D Miller… - …, 2022 - rep.bioscientifica.com
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Maternal and fetal T cells in term pregnancy and preterm labor

D Miller, M Gershater, R Slutsky, R Romero… - Cellular & Molecular …, 2020 - nature.com
Pregnancy is a state of immunological balance during which the mother and the developing
fetus must tolerate each other while maintaining sufficient immunocompetence to ward off …

Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing

V Garcia-Flores, R Romero, AL Tarca… - Science translational …, 2024 - science.org
Labor is a complex physiological process requiring a well-orchestrated dialogue between
the mother and fetus. However, the cellular contributions and communications that facilitate …

Comprehensive human amniotic fluid metagenomics supports the sterile womb hypothesis

HC Wang, GX Yang, Y Hu, P Lam, K Sangha… - Scientific Reports, 2022 - nature.com
As metagenomic approaches for detecting infectious agents have improved, each tissue that
was once thought to be sterile has been found to harbor a variety of microorganisms …

Clinical chorioamnionitis at term X: microbiology, clinical signs, placental pathology, and neonatal bacteremia–implications for clinical care

R Romero, P Pacora, JP Kusanovic, E Jung… - Journal of perinatal …, 2021 - degruyter.com
Objectives Clinical chorioamnionitis at term is considered the most common infection-related
diagnosis in labor and delivery units worldwide. The syndrome affects 5–12% of all term …

Sneathia: an emerging pathogen in female reproductive disease and adverse perinatal outcomes

KR Theis, V Florova, R Romero… - Critical reviews in …, 2021 - Taylor & Francis
Sneathia is an emerging pathogen implicated in adverse reproductive and perinatal
outcomes. Although scarce, recent data suggest that vaginally residing Sneathia becomes …

A single-cell atlas of murine reproductive tissues during preterm labor

V Garcia-Flores, R Romero, A Peyvandipour, J Galaz… - Cell reports, 2023 - cell.com
Preterm birth, the leading cause of perinatal morbidity and mortality worldwide, frequently
results from the syndrome of preterm labor. The best-established causal link to preterm labor …

[HTML][HTML] RNA sequencing reveals diverse functions of amniotic fluid neutrophils and monocytes/macrophages in intra-amniotic infection

N Gomez-Lopez, R Romero, A Varrey, Y Leng… - Journal of Innate …, 2021 - karger.com
Intra-amniotic infection, the invasion of microbes into the amniotic cavity resulting in
inflammation, is a clinical condition that can lead to adverse pregnancy outcomes for the …

RNA sequencing reveals distinct immune responses in the chorioamniotic membranes of women with preterm labor and microbial or sterile intra-amniotic …

K Motomura, R Romero, J Galaz, AL Tarca… - Infection and …, 2021 - Am Soc Microbiol
Preterm labor precedes premature birth, the leading cause of neonatal morbidity and
mortality worldwide. Preterm labor can occur in the context of either microbe-associated intra …