Reactive oxidant species (ROS) are unstable, highly reactive molecules that are produced
by cells either as byproducts of metabolism or synthesized by specialized enzymes. ROS …

The emergence of drug resistance is the most substantial challenge to the effectiveness of
anticancer therapies. Orthogonal approaches have revealed that a subset of cells, known as …

Tackling the challenge created by antibiotic resistance requires understanding the
mechanisms behind its evolution. Like any evolutionary process, the evolution of …

Emergence of drug-induced antimicrobial resistance (AMR) forms a crippling health and
economic crisis worldwide, causing high mortality from otherwise treatable diseases and …

Highlights•Networks have been successfully applied in biology and medicine for several
decades.•Network methods play a key role in personalized and precision medicine.•Rapid …

Background/Objectives: The rise and spread of antimicrobial resistance complicates the
treatment of bacterial wound pathogens, further increasing the need for newer, effective …

The abuse of antibiotics has become a global public safety issue, leading to the
development of antimicrobial resistance (AMR). The development of antimicrobial …

Exposure to environmental stressors, including certain antibiotics, induces stress responses
in bacteria. Some of these responses increase mutagenesis and thus potentially accelerate …

Our laboratory recently reported that induction of the SOS response, triggered by SOS-
inducing drugs, was accompanied by a large release of DNA from enteric bacteria. The SOS …

Nearly 150 million cases of urinary tract infections (UTIs) are reported each year, of which
uncomplicated cystitis triggers> 25% of outpatient prescriptions of oral antimicrobial …