Epigenetic Factors and ncRNAs in Testicular Cancer

D Nuñez-Corona, E Contreras-Sanzón… - International Journal of …, 2023 - mdpi.com
Testicular cancer is the most prevalent tumor among males aged 15 to 35, resulting in a
significant number of newly diagnosed cases and fatalities annually. Non-coding RNAs …

High-throughput CRISPR screening in hematological neoplasms

R Ancos-Pintado, I Bragado-García, ML Morales… - Cancers, 2022 - mdpi.com
Simple Summary High-throughput CRISPR screening provides an unbiased way for
functional genomic studies in hematological malignancies. This approach has been used to …

ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 …

G Batbayar, A Ishimura, H Lyu, S Wanna-Udom… - Biochemical and …, 2023 - Elsevier
Abstract ASH2L (Absent-Small-Homeotic-2-Like protein) is a core subunit of the COMPASS
(COMplex of Proteins ASsociated with Set1) complex, the most notable writer of the …

ASH2L 在幽门螺旋杆菌感染的人胃癌细胞系中的表达及临床意义

谢晓婷, 张雷, 张莉, 董凤, 刘颖… - 基础医学与 …, 2023 - journal11.magtechjournal.com
目的探索果蝇蛋白Ash2 的类似物(ASH2L) 在幽门螺旋杆菌(Hp) 感染的人胃癌细胞系中的表达
水平及临床意义. 方法利用TIMER2. 0, UALCAN 等生物信息软件分析ASH2L …

Epigenetics and testicular cancer: bridging the gap between fundamental biology and patient care

AT Nicu, C Medar, MC Chifiriuc… - Frontiers in Cell and …, 2022 - frontiersin.org
Testicular cancer is the most common solid tumor affecting young males. Most testicular
cancers are testicular germ cell tumors (TGCTs), which are divided into seminomas (SGCTs) …

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic) 2-like protein (ASH2L) as a regulator of glioblastoma cell survival

E Ozyerli-Goknar, EY Kala, AC Aksu, I Bulut… - Cell Communication and …, 2023 - Springer
Background Glioblastoma is the most common and aggressive primary brain tumor with
extremely poor prognosis, highlighting an urgent need for developing novel treatment …

Harnessing bacterial metabolites for enhanced cancer chemotherapy: unveiling unique therapeutic potentials

A Chatterjee, R Khan, T Mukherjee, PP Sahoo… - Archives of …, 2024 - Springer
Cancer poses a serious threat to health globally, with millions diagnosed every year.
According to Global Cancer Statistics 2024, about 20 million new cases were reported in …

Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes reduces chromatin accessibility at promoters

M Barsoum, AT Stenzel, A Bochyńska, CC Kuo… - Scientific Reports, 2022 - nature.com
Abstract Changes in gene expression programs are intimately linked to cell fate decisions.
Post-translational modifications of core histones contribute to control gene expression …

[HTML][HTML] “Pass the Genetic Scalpel”: A Comprehensive Review of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) in Urological Cancers

A Yim, M Alberto, M Herold, D Woon, J Ischia… - Société Internationale d' …, 2024 - mdpi.com
Introduction: Urological cancers account for a significant portion of cancer diagnoses and
mortality rates worldwide. The traditional treatment options of surgery and chemoradiation …

The impact of immunological checkpoint inhibitors and targeted therapy on chronic pruritus in cancer patients

A Allegra, E Di Salvo, M Casciaro, C Musolino… - Biomedicines, 2020 - mdpi.com
Although pruritus may sometimes be a consequential situation to neoplasms, it more
frequently emerges after commencing chemotherapy. In this review, we present our analysis …