Basic mechanisms of diabetic heart disease
RH Ritchie, ED Abel - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning
SA Langhans - Frontiers in pharmacology, 2018 - frontiersin.org
Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …
from target identification to lead discovery and optimization, preclinical validation and …
Capturing cardiogenesis in gastruloids
Organoids are powerful models for studying tissue development, physiology, and disease.
However, current culture systems disrupt the inductive tissue-tissue interactions needed for …
However, current culture systems disrupt the inductive tissue-tissue interactions needed for …
3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels
Cellular models are needed to study human development and disease in vitro, and to
screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of …
screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of …
Strategies for 3D bioprinting of spheroids: A comprehensive review
Biofabricated tissues have found numerous applications in tissue engineering and
regenerative medicine in addition to the promotion of disease modeling and drug …
regenerative medicine in addition to the promotion of disease modeling and drug …
Engineering vascularized organoid-on-a-chip models
VS Shirure, CCW Hughes… - Annual Review of …, 2021 - annualreviews.org
Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
[HTML][HTML] Progress in multicellular human cardiac organoids for clinical applications
Advances in self-organizing cardiac organoids to recapitulate human cardiogenesis have
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …
3D co-culture of hiPSC-derived cardiomyocytes with cardiac fibroblasts improves tissue-like features of cardiac spheroids
P Beauchamp, CB Jackson, LC Ozhathil… - Frontiers in molecular …, 2020 - frontiersin.org
Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac
development, function, and remodeling. Properties of 3D co-cultures are incompletely …
development, function, and remodeling. Properties of 3D co-cultures are incompletely …
A heart‐breast cancer‐on‐a‐chip platform for disease modeling and monitoring of cardiotoxicity induced by cancer chemotherapy
Cardiotoxicity is one of the most serious side effects of cancer chemotherapy. Current
approaches to monitoring of chemotherapy‐induced cardiotoxicity (CIC) as well as model …
approaches to monitoring of chemotherapy‐induced cardiotoxicity (CIC) as well as model …
Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
MF Tenreiro, AF Louro, PM Alves… - NPJ Regenerative …, 2021 - nature.com
The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …
capability of self-repair and regeneration in case of injury or disease. Engineering …