Germline aberrations in critical DNA-repair and DNA damage–response (DDR) genes
cause cancer predisposition, whereas various tumors harbor somatic mutations causing …

Abstract Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) acts as a DNA damage sensor. It
recognizes DNA damage and facilitates DNA repair by recruiting DNA repair machinery to …

Reactive oxygen species continuously assault the structure of DNA resulting in oxidation
and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair …

When describing the structure of the DNA double helix, Watson and Crick (1) wrote,“It has
not escaped our notice that the specific pairing we have postulated immediately suggests a …

Base excision repair (BER) is an evolutionarily conserved pathway, which could be
considered the “workhorse” repair mechanism of the cell. In particular, BER corrects most …

DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base
excision repair, or directly from damage to deoxyribose. Because single-strand breaks are …

Before a deleterious DNA lesion can be replaced with its undamaged counterpart, the lesion
must first be removed from the genome. This process of removing and replacing DNA …

The paradigm for repair of oxidized base lesions in genomes via the base excision repair
(BER) pathway is based on studies in Escherichia coli, in which AP endonuclease (APE) …

TREX1, originally designated DNase III, was isolated as a major nuclear DNA-specific 3′→
5′ exonuclease that is widely distributed in both proliferating and nonproliferating …

DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis
utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped …