Studies of human addicts and behavioural studies in rodent models of addiction indicate that
key behavioural abnormalities associated with addiction are extremely long lived. So …

The faithful execution of biological processes requires a precise and carefully orchestrated
set of steps that depend on the proper spatial and temporal expression of genes. Here we …

Regulation of biological processes typically incorporates mechanisms that initiate and
terminate the process and, where understood, these mechanisms often involve feedback …

Learning to read and write the transcriptional regulatory code is of central importance to
progress in genetic analysis and engineering. Here we describe a massively parallel …

This book unifies and extends latent variable models, including multilevel or generalized
linear mixed models, longitudinal or panel models, item response or factor models, latent …

The glucocorticoid (GC) receptor (GR), when liganded to GC, activates transcription through
direct binding to simple (+) GRE DNA binding sequences (DBS). GC-induced direct …

Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …

Inflammation is an essential response provided by the immune systems that ensures the
survival during infection and tissue injury. Inflammatory responses are essential for the …

The longevity of some of the behavioral abnormalities that characterize drug addiction has
suggested that regulation of neural gene expression may be involved in the process by …

Transcriptional activation of the interferon-β (IFN-β) gene requires assembly of an
enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFκB. These factors bind …