Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …

System xc‐is an amino acid antiporter that typically mediates the exchange of extracellular l‐
cystine and intracellular l‐glutamate across the cellular plasma membrane. Studied in a …

Glutamate receptor-mediated excitatory neurotransmission plays a key role in neural
development, differentiation and synaptic plasticity. However, excessive stimulation of …

Glutamate transporters play important roles in the termination of excitatory
neurotransmission and in providing cells throughout the body with glutamate for metabolic …

Glutamate transporters remove the excitatory neurotransmitter glutamate from the
extracellular space after neurotransmission is complete, by taking glutamate up into neurons …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post‐synaptic neuronal
element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2 …

Photopharmacology addresses the challenge of drug selectivity and side effects through
creation of photoresponsive molecules activated with light with high spatiotemporal …

The neuronal excitatory amino acid transporter 3 (EAAT3) is fairly ubiquitously expressed in
the brain, though it does not necessarily maintain the same function everywhere. It is …