Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory
event, and the enzymes catalyzing these modifications have been the focus of many studies …

Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability
to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at …

Given the manifold ways that depression impairs Darwinian fitness, the persistence in the
human genome of risk alleles for the disorder remains a much debated mystery …

Snail1, a key transcription factor of epithelial–mesenchymal transition (EMT), is subjected to
ubiquitination and degradation, but the mechanism by which Snail1 is stabilized in tumours …

The transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2) is one of the master
regulators that control hundreds of genes containing antioxidant response elements (AREs) …

Regulatory functions of the ubiquitin-proteasome system (UPS) are exercised mainly by the
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …

Malfunction of ubiquitin-proteasome system is tightly linked to tumor formation and tumor
metastasis. Targeting the ubiquitin-pathway provides a new strategy for anti-cancer therapy …

Deubiquitinases (DUBs) are involved in various cellular functions. They deconjugate
ubiquitin (UBQ) from ubiquitylated substrates to regulate their activity and stability. Studies …

CD33 is a member of the sialic acid–binding immunoglobulin-like lectin (Siglec) family of
inhibitory receptors and a therapeutic target for acute myeloid leukemia (AML). CD33 …

It has become apparent that ubiquitination plays a critical role in cell survival and cell death.
In addition, deubiquitinating enzymes (DUBs) have been determined to be highly important …