The cholesterol-lowering effect of oats and oat beta glucan: modes of action and potential role of bile acids and the microbiome
Consumption of sufficient quantities of oat products has been shown to reduce host
cholesterol and thereby modulate cardiovascular disease risk. The effects are proposed to …
cholesterol and thereby modulate cardiovascular disease risk. The effects are proposed to …
[HTML][HTML] Role of farnesoid X receptor in hepatic steatosis in nonalcoholic fatty liver disease
Y Xi, H Li - Biomedicine & Pharmacotherapy, 2020 - Elsevier
With the increased incidence of obesity, nonalcoholic fatty liver disease (NAFLD) has
become a major global health concern. The pathogenesis of NAFLD has not yet been fully …
become a major global health concern. The pathogenesis of NAFLD has not yet been fully …
Multiomics study of nonalcoholic fatty liver disease
G Sveinbjornsson, MO Ulfarsson, RB Thorolfsdottir… - Nature …, 2022 - nature.com
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed
a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and …
a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and …
[HTML][HTML] The mobility pattern of dockless bike sharing: A four-month study in Singapore
Many cities around the world have adopted dockless bike-sharing programs with the hope
that this new service could enhance last-mile public transit connections. However, our …
that this new service could enhance last-mile public transit connections. However, our …
Pla2g12b drives expansion of triglyceride-rich lipoproteins
JH Thierer, O Foresti, PK Yadav, MH Wilson… - nature …, 2024 - nature.com
Vertebrates transport hydrophobic triglycerides through the circulatory system by packaging
them within amphipathic particles called Triglyceride-Rich Lipoproteins. Yet, it remains …
them within amphipathic particles called Triglyceride-Rich Lipoproteins. Yet, it remains …
[HTML][HTML] Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development
M Yang, Q Liu, T Huang, W Tan, L Qu, T Chen… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Men and postmenopausal women are more prone to developing non-alcoholic
fatty liver disease/steatohepatitis (NAFLD/NASH) than premenopausal women. However …
fatty liver disease/steatohepatitis (NAFLD/NASH) than premenopausal women. However …
[HTML][HTML] Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism
V Massafra, SWC van Mil - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Abstract The Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs).
BAs are amphipathic molecules that serve as fat solubilizers in the intestine under …
BAs are amphipathic molecules that serve as fat solubilizers in the intestine under …
Enterohepatic and non-canonical roles of farnesoid X receptor in controlling lipid and glucose metabolism
W Zhou, S Anakk - Molecular and cellular endocrinology, 2022 - Elsevier
Farnesoid X receptor (FXR) is a nuclear receptor that transcriptionally regulates bile acid
homeostasis along with nutrient metabolism. In addition to the gastrointestinal (GI) tract, FXR …
homeostasis along with nutrient metabolism. In addition to the gastrointestinal (GI) tract, FXR …
[HTML][HTML] Integrated transcriptomics and metabolomics analysis of the intestine of cobia (Rachycentron canadum) under hypoxia stress
E Yang, E Amenyogbe, J Zhang, W Wang, J Huang… - Aquaculture …, 2022 - Elsevier
In intensive aquaculture systems, dissolved oxygen (DO) is the most critical and limiting
factor for the development and health of aquatic organisms. Hypoxia is a common …
factor for the development and health of aquatic organisms. Hypoxia is a common …
Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation
DG Zhang, C Zhang, JX Wang, BW Wang… - Toxicology and Applied …, 2017 - Elsevier
The farnesoid X receptor (FXR) is a ligand-activated transcription factor that plays important
roles in regulating bile acid homeostasis. The aim of the present study was to investigate the …
roles in regulating bile acid homeostasis. The aim of the present study was to investigate the …