The cholesterol-lowering effect of oats and oat beta glucan: modes of action and potential role of bile acids and the microbiome

SA Joyce, A Kamil, L Fleige, CGM Gahan - Frontiers in nutrition, 2019 - frontiersin.org
Consumption of sufficient quantities of oat products has been shown to reduce host
cholesterol and thereby modulate cardiovascular disease risk. The effects are proposed to …

[HTML][HTML] Role of farnesoid X receptor in hepatic steatosis in nonalcoholic fatty liver disease

Y Xi, H Li - Biomedicine & Pharmacotherapy, 2020 - Elsevier
With the increased incidence of obesity, nonalcoholic fatty liver disease (NAFLD) has
become a major global health concern. The pathogenesis of NAFLD has not yet been fully …

Multiomics study of nonalcoholic fatty liver disease

G Sveinbjornsson, MO Ulfarsson, RB Thorolfsdottir… - Nature …, 2022 - nature.com
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed
a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and …

[HTML][HTML] The mobility pattern of dockless bike sharing: A four-month study in Singapore

X Zhang, Y Shen, J Zhao - Transportation Research Part D: Transport and …, 2021 - Elsevier
Many cities around the world have adopted dockless bike-sharing programs with the hope
that this new service could enhance last-mile public transit connections. However, our …

Pla2g12b drives expansion of triglyceride-rich lipoproteins

JH Thierer, O Foresti, PK Yadav, MH Wilson… - nature …, 2024 - nature.com
Vertebrates transport hydrophobic triglycerides through the circulatory system by packaging
them within amphipathic particles called Triglyceride-Rich Lipoproteins. Yet, it remains …

[HTML][HTML] Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development

M Yang, Q Liu, T Huang, W Tan, L Qu, T Chen… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Men and postmenopausal women are more prone to developing non-alcoholic
fatty liver disease/steatohepatitis (NAFLD/NASH) than premenopausal women. However …

[HTML][HTML] Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism

V Massafra, SWC van Mil - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
Abstract The Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs).
BAs are amphipathic molecules that serve as fat solubilizers in the intestine under …

Enterohepatic and non-canonical roles of farnesoid X receptor in controlling lipid and glucose metabolism

W Zhou, S Anakk - Molecular and cellular endocrinology, 2022 - Elsevier
Farnesoid X receptor (FXR) is a nuclear receptor that transcriptionally regulates bile acid
homeostasis along with nutrient metabolism. In addition to the gastrointestinal (GI) tract, FXR …

[HTML][HTML] Integrated transcriptomics and metabolomics analysis of the intestine of cobia (Rachycentron canadum) under hypoxia stress

E Yang, E Amenyogbe, J Zhang, W Wang, J Huang… - Aquaculture …, 2022 - Elsevier
In intensive aquaculture systems, dissolved oxygen (DO) is the most critical and limiting
factor for the development and health of aquatic organisms. Hypoxia is a common …

Obeticholic acid protects against carbon tetrachloride-induced acute liver injury and inflammation

DG Zhang, C Zhang, JX Wang, BW Wang… - Toxicology and Applied …, 2017 - Elsevier
The farnesoid X receptor (FXR) is a ligand-activated transcription factor that plays important
roles in regulating bile acid homeostasis. The aim of the present study was to investigate the …