The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Sirtuins are a conserved family of proteins found in all domains of life. The first known sirtuin,
Sir2 (silent information regulator 2) of Saccharomyces cerevisia e, from which the family …

Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones …

Sirtuins post-translationally modulate the function of many cellular proteins that undergo
reversible acetylation–deacetylation cycles, affecting physiological responses that have …

Abstract Sirtuin 1 (S IRT1), the mammalian homolog of SIR2, was originally identified as a
NAD-dependent histone deacetylase, the activity of which is closely associated with lifespan …

Changes in cellular nutrient availability or energy status induce global changes in
mitochondrial protein acetylation. Over one-third of all proteins in the mitochondria are …

Summary Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein
deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to …

Mortality and morbidity from cardiovascular diseases (CVDs) represents a huge burden to
society. It is recognized that environmental factors and individual lifestyles play important …

Heart failure is one of the leading causes of mortality in the western world and encompasses
a wide spectrum of cardiac pathologies. When the heart experiences extended periods of …

Histone deacetylases (Hdacs) are conserved enzymes that remove acetyl groups from
lysine side chains in histones and other proteins. Eleven of the 18 Hdacs encoded by the …