Objective To ascertain contemporary approaches to the collection, reporting and analysis of
adverse events (AEs) in randomised controlled trials (RCTs) with a primary efficacy …

Background Noninferiority trials are increasingly common, though they have less
standardized designs and their interpretation is less familiar to clinicians than superiority …

Background The latent viral reservoir is the major obstacle to achieving HIV remission and
necessitates life-long antiretroviral therapy (ART) for HIV-infected individuals. Studies in …

How and when to disclose a positive HIV diagnosis to an infected child is a complex
challenge for caregivers and healthcare workers. With the introduction of antiretroviral …

Perinatally-acquired HIV has persistent effects on long-term health outcomes, even after
early treatment. We hypothesize that epigenetic indicators, such as DNA methylation, may …

Objective: The report of the 'Mississippi baby'who was initiated on antiretroviral therapy
(ART) within 30 h of birth and maintained viral suppression off ART for 27 months has …

Background Prior research in sub-Saharan Africa reports dyslipidemia in perinatally human
immunodeficiency virus (HIV)-infected children receiving ritonavir-boosted lopinavir (LPV/r) …

Background: We investigate if switching from a ritonavir-boosted lopinavir (LPV/r)-based to
an efavirenz-based antiretroviral therapy (ART) regimen is associated with beneficial bone …

Children living with HIV (CLHIV) have decreased bone mineral content (BMC) and density
(BMD), increasing risk for fracture and future osteoporosis. While DXA is the gold-standard …

Objective: We evaluated longitudinal trends and associations between bone mass, bone
turnover and inflammatory markers among South African children living with HIV (CLHIV) …