Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …

While most of the efforts to uncover mechanisms contributing to bipolar disorder (BD)
focused on phenotypes at the mature neuron stage, little research has considered events …

Cell proliferation is orchestrated through diverse proteins related to calcium (Ca 2+)
signaling inside the cell. Cellular Ca 2+ influx that occurs first by various mechanisms at the …

Calcium signals, pivotal in controlling cell function, can be generated by calcium entry
channels activated by plasma membrane depolarization or depletion of internal calcium …

Introduction• I CRAC• Orais• STIM1• STIM2• STIM1, STIM2 and Ca2+ oscillations• TRPCs
and SOCE• Conclusions The process of store‐operated Ca2+ entry (SOCE), whereby Ca2+ …

The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …

A rise in cytosolic Ca 2+ concentration is used as a universal signalling mechanism to
control biological processes as diverse as exocytosis, contraction, cell growth and cell …

Eukaryotic organelles can interact with each other through stable junctions where the two
membranes are kept in close apposition. The junction that connects the endoplasmic …

The ER membrane-spanning STIM1 protein is a finely-tuned sensor of ER luminal Ca 2+.
Small changes in ER Ca 2+ induce STIM1 to undergo an intricate self-triggering process …