Applications of small-angle X-ray scattering (SAXS) in structural biology are reviewed. A
brief introduction of the SAXS basics is followed by the presentation of the structural features …

Highlights•Protein complexes of the SMC family organize chromosomes by extruding large
DNA loops.•SMC-mediated loop extrusion presumably requires DNA anchor and motor …

Condensin and cohesin, both members of the structural maintenance of chromosome (SMC)
family, contribute to the regulation and structure of chromatin. Recent work has shown both …

Background Eukaryotic cells have a continuous transit of macromolecules between the
cytoplasm and the nucleus. Several carrier proteins are involved in this transport. One of …

MDM2 is an E3 ubiquitin ligase which is crucial for the degradation and inhibition of the key
tumor-suppressor protein p53. In this work, we explored the stability and the conformational …

Abstract Plakophilin 1 (PKP1) is a member of the armadillo repeat family of proteins. It
serves as a scaffold component of desmosomes, which are key structural components for …

Deposition of histone H3 lysine 4 (H3K4) methylation at promoters is catalyzed by the
SET1/COMPASS complex and is associated with context-dependent effects on gene …

Abstract Neurofibromin-1 (NF1) is a large, multidomain tumour suppressor encoded by the
NF1 gene. The gene is mutated in neurofibromatosis type I, a disease characterized by …

During cell division, the genetic material of each cell, the DNA undergoes the most drastic
rearrangements. The amorphous interphase chromatin condenses into short discernable …

Bacterial effector proteins translocated via a type-IV secretion system (T4SS) typically harbor
a C-terminal segment required for recognition by the type-IV secretion coupling protein 1. In …