The targeted and efficiency-oriented delivery of (therapeutic) nucleic acids raises hope for
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …

Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to
recognize a homologous mRNA sequence in the cell and induce its degradation. The main …

Avidin-biotin interaction is one of the strongest non-covalent interactions in the nature.
Avidin and its analogues have therefore been extensively utilized as probes and affinity …

Recent advances in tumor immunotherapy mainly tend to remodel the immunosuppressive
tumor microenvironment (TME) for immune enhancement. However, the complexity of TME …

Understanding the cellular uptake and intracellular trafficking of oligonucleotides provides
an important basic underpinning for the developing field of oligonucleotide-based …

RNA therapeutics (eg siRNA, oligonucleotides, mRNA, etc.) show great potential for the
treatment of a myriad of diseases. However, to reach their site of action in the cytosol or …

Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles
have been studied extensively for various drug deliveries, to treat or prevent diseases by …

RNAi is a remarkable treatment strategy to knock down gene overexpression in a variety of
disorders, including cancers. RNAi processes allow siRNAs to detect and degrade a …

Lung cancer is a major contributor to cancer-related death worldwide. siRNA
nanomedicines are powerful tools for cancer therapeutics. However, there are challenges to …

Purpose Cervical cancer is one of the most common causes of death among women
globally. Combinations of cisplatin, paclitaxel, bevacizumab, carboplatin, topotecan, and …