Diabetic retinal disease (DRD), the most common complication of diabetes and a leading
cause of blindness in working age individuals, is now understood to be a form of sensory …

Electrotransfer of nucleic acids and proteins has become crucial in biotechnology for gene
augmentation and genome editing. This review explores the applications of electrotransfer …

An extreme chronic wound tissue microenvironment causes epigenetic gene silencing. An
unbiased whole-genome methylome was studied in the wound-edge tissue of patients with …

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Tissue injury to skin diminishes miR-200b in dermal fibroblasts. Fibroblasts are widely
reported to directly reprogram into endothelial-like cells and we hypothesized that miR-200b …

Extracellular vesicles (EVs) are nanovesicles released by all eukaryotic cells. This work
reports the first nanoscale fluorescent visualization of tumor-originating vesicles bearing an …

Therapeutic vascular endothelial growth factor (VEGF) replenishment has met with limited
success for the management of critical limb-threatening ischemia. To improve outcomes of …

Fetal cutaneous wound closure and repair differ from that in adulthood. In this work, we
identify an oxidant stress sensor protein, nonselenocysteine-containing phospholipid …

Gene delivery has revolutionized conventional medical approaches to vaccination, cancer,
and autoimmune diseases. However, current gene delivery methods are limited to either …

Cellular uptake of exogenous nucleic acids is inhibited in pathological tissues accompanied
by excessive expression of matrix metalloproteinases (MMPs). We show that CO, as a …