The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Linking EMT programmes to normal and neoplastic epithelial stem cells

AW Lambert, RA Weinberg - Nature Reviews Cancer, 2021 - nature.com
Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

J Haerinck, S Goossens, G Berx - Nature Reviews Genetics, 2023 - nature.com
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Epithelial-mesenchymal plasticity in cancer progression and metastasis

W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

Controversies around epithelial–mesenchymal plasticity in cancer metastasis

ED Williams, D Gao, A Redfern… - Nature Reviews Cancer, 2019 - nature.com
Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

Context-dependent EMT programs in cancer metastasis

NM Aiello, Y Kang - Journal of Experimental Medicine, 2019 - rupress.org
Epithelial–mesenchymal transition (EMT) is a developmental process whereby stationary,
adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements …

Cancer drug resistance induced by EMT: novel therapeutic strategies

J De Las Rivas, A Brozovic, S Izraely, A Casas-Pais… - Archives of …, 2021 - Springer
Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …

Epithelial‐to‐mesenchymal transition in oral squamous cell carcinoma: challenges and opportunities

Z Ling, B Cheng, X Tao - International journal of cancer, 2021 - Wiley Online Library
Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90%
of all forms of oral cancer worldwide. Although great efforts have been made in the past …

Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

Y Katsuno, R Derynck - Developmental cell, 2021 - cell.com
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …

Update on epithelial-mesenchymal plasticity in cancer progression

R Fontana, A Mestre-Farrera… - Annual Review of …, 2024 - annualreviews.org
Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells lose
their characteristics and acquire mesenchymal traits to promote cell movement. This …