We review the morphofunctional characteristics of pericytes and report our observations.
After a brief historical background, we consider the following aspects of pericytes: A) Origin …

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and
promote the development of cardiovascular disease (CVD) and diabetes. Recent genome …

The epigenome consists of non–sequence-based modifications, such as DNA methylation,
that are heritable during cell division and that may affect normal phenotypes and …

Quantitative trait locus (QTL) analysis is a statistical method that links two types of
information—phenotypic data (trait measurements) and genotypic data (usually molecular …

There remains a need for robust mouse models of diabetic nephropathy (DN) that mimic key
features of advanced human DN. The recently developed mouse strain BTBR with the ob/ob …

Insulin-producing β cells become dedifferentiated during diabetes progression. An impaired
ability to select substrates for oxidative phosphorylation, or metabolic inflexibility, initiates …

During the first 100 years of Alzheimer's disease research, this devastating and intractable
disorder has been characterized at the clinical, histological, and molecular levels …

VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class
of type-1 receptors that are expressed in neurons. Family members are multifunctional …

Inbred mouse strains provide genetic diversity comparable to that of the human population.
Like humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse …

The family of mammalian type-I transmembrane receptors containing a Vps10p domain
contains five members, Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common …