Subcellular organelles are the cornerstones of cells, and destroying them will cause cell
dysfunction and even death. Therefore, realizing precise organelle targeting of …

Nanoparticles (NPs) have emerged as an effective modality for the treatment of various
diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs …

Engineered nanoparticles have the potential to revolutionize the diagnosis and treatment of
many diseases; for example, by allowing the targeted delivery of a drug to particular subsets …

The overview covers the discovery of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers, initial studies on their synthesis, evaluation of biological properties, and …

This overview focuses on bioconjugates of water-soluble polymers with low molecular
weight drugs and proteins. After a short discussion of the origins of the field, the state-of-the …

Polymerization reactions conducted inside cells must be compatible with the complex
intracellular environment, which contains numerous molecules and functional groups that …

Mutations in the KRAS proto-oncogene are present in 50% of all colorectal cancers and are
increasingly associated with chemotherapeutic resistance to frontline biologic drugs …

Mitochondria-targeted photodynamic therapy (PDT) has emerged as one of the most
efficient antitumor strategies. However, the therapeutic outcome of mitochondria-targeted …

Sulfite oxidase is a mitochondria-located molybdenum-containing enzyme catalyzing the
oxidation of sulfite to sulfate in the amino acid and lipid metabolism. Therefore, it plays a …

In recent years, a new generation of drugs has entered the pharmaceutical market. Some
are more potent, but some are also more toxic and thus, therapeutical efficacy may be …