Cartilage degeneration is among the fundamental reasons behind disability and pain across
the globe. Numerous approaches have been employed to treat cartilage diseases …

Annually, millions of patients suffer from irreversible injury owing to the loss or failure of an
organ or tissue caused by accident, aging, or disease. The combination of injectable …

Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis
leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the …

Introducing hydration layers to hydrogel microspheres (HMs) by coating the surface with
liposomes can effectively reduce friction. However, the lubrication can be inactivated when …

Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA),
but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections …

Particle-based drug delivery systems have a demonstrated value in osteoarthritis treatment.
Research in this area trends to developing functional particles to improve the therapeutic …

Cyclodextrin (CD) is one of the most versatile substances produced by nature and can form
supramolecular hydrogels with polymers or small molecules based on non-covalent …

Clinically, intra-articular administration can hardly achieve the truly targeted therapy, and the
drugs are usually insufficient to show local and long-term therapeutic effects because of their …

The osteoarthritis (OA) symptoms cannot be fully remedied by using only a single functional
component because of its complex pathogenesis. Herein, a MnO 2 nanozyme-encapsulated …

Increasing data reveals that gelatin that has been methacrylated is involved in a variety of
physiologic processes that are important for therapeutic interventions. Gelatin methacryloyl …